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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway

Fig. 3

GCAFs promote the tumor growth and VM formation of GBC in vivo. A. Size, volume and growth curves of tumor xenografts in GBC-SD + GCAFs group were significantly larger than that of GBC-SD group (all *P < 0.05). B. (b1. HE staining, b2. CD31-PAS double staining; × 200). Sections of the xenografts in GBC-SD group and GBC-SD + GCAFs group showed tumor cell-lined vessel-like structure with single or multiple red blood cells inside (red arrowhead) without any evidence of tumor necrosis, and PAS-positive substances line the channel-like structures (yellow arrowhead). Of them, more tumor cell-lined vessel-like structures with multiple red blood cell inside and more PAS-positive substances lining the channel-like structures of the xenograft sections in GBC-SD + GCAFs group were observed. TEM (B3.; original magnification, × 8000) clearly visualized single (GBC-SD group) or multiple (GBC-SD + GCAFs group) red blood cells in the central of tumor nests in the xenografts (red arrowhead)

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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