Table 1 Correlation between NOX4 expression in tumor cells and clinicopathological parameters in patients with gallbladder cancer
Variable | NOX4 expression [n (%)] | x2 value (P) | Spearman rank correlation, r (P) | |
|---|---|---|---|---|
Low | High | |||
Age (y) | ||||
 > 65 | 13 (40.6) | 19 (59.4) | 0.127 (0.649) | 0.013 (0.834) |
 ≤ 65 | 23 (43.3) | 30 (56.7) | ||
Gender | ||||
 Male | 26 (52) | 24 (48) | 1.153 (0.361) | 0.244 (0.120) |
 Female | 12 (34.2) | 23 (65.8) | ||
Tumor location | ||||
 Bottom | 20 (47.6) | 22 (52.4) | 0.689 (0.388) | 0.105 (0.505) |
 Neck and other | 15 (34.9) | 28 (65.1) | ||
Tumor size (cm) | ||||
 > 3 | 19 (42.2) | 26 (57.8) | 0.734 (0.289) | 0.125 (0.434) |
 ≤ 3 | 19 (47.5) | 21 (52.5) | ||
Histological types | ||||
 Adenocarcinoma | 29 (35.8) | 52 (64.2) | 0.093 (0.672) | 0.272 (0.345) |
 Other a | 1 (25) | 3 (75) | ||
Differentiation degree | ||||
 High | 7 (63.6) | 4 (36.4) | 7.676 (0.018) b | 0.422 (0.004) b |
 Moderate | 16 (47) | 18 (53) | ||
 Poor | 8 (20) | 32 (80) | ||
Liver metastases | ||||
 (+) | 15 (33.3) | 30 (66.7) | 4.715 (0.030) b | 0.334 (0.032) b |
 (−) | 21 (52.5) | 19 (47.5) | ||
Vascular invasion | ||||
 (+) | 13 (27) | 35 (73) | 5.904 (0.025) b | 0.352 (0.028) b |
 (−) | 15 (40.5) | 22 (59.5) | ||
Lymph node metastasis | ||||
 (+) | 15 (33.3) | 30 (66.7) | 1.656 (0.198) | 0.053 (0.635) |
 (−) | 19 (47.5) | 21 (52.5) | ||
Nevin staging | ||||
 III, IV, V | 21 (32.8) | 43 (67.2) | 6.125 (0.019) b | 0.382 (0.025) b |
 I, II | 10 (47.6) | 11 (52.4) | ||
Resection method | ||||
 R1, R2 | 14 (32.5) | 29 (67.5) | 1.660 (0.202) | 0.055 (0.644) |
 R0 | 20(47.6) | 22(52.4) | ||
VM | ||||
 (+) | 18 (81.8) | 4 (18.2) | 6.625 (0.017) b | 0.321 (0.016) b |
 (−) | 12 (19.1) | 51 (80.9) | ||