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Table 3 Cox model analysis of influencing factors of survival prognosis in patients with gallbladder cancer

From: Gallbladder cancer-associated fibroblasts promote vasculogenic mimicry formation and tumor growth in gallbladder cancer via upregulating the expression of NOX4, a poor prognosis factor, through IL-6-JAK-STAT3 signal pathway

Variable Single factor Multiple factors
HR 95% CI P HR 95% CI P
Gender
 Male vs. female 0.972 0.609–1.554 0.907    
Age (y)
 > 65 vs. ≤65 0.808 0.517–1.262 0.348    
Tumor site
 Bottom vs. neck etc. 0.755 0.481–1.184 0.221    
Tumor size (cm)
 > 3.0 vs. ≤3.0 1.434 0.909–2.262 0.121    
Histological types
 Adenocarcinoma vs. others b 0.255 0.106–0.613 0.002a    
Differentiation degree
 High vs. medium/low 0.243 0.114–0.514 0.000a 0.437 0.196–0.975 0.039 a
Nevin staging
 III ~ V vs. I ~ II 2.482 1.227–5.021 0.011a    
Liver invasion
 (+) vs. (−) 2.075 1.294–3.327 0.002a 1.949 1.187–3.201 0.012 a
Vascular invasion
 (+) vs. (−) 3.235 1.911–5.475 0.000a 2.569 1.486–4.444 0.003 a
Lymph node metastasis
 (+) vs. (−) 1.708 1.057–2.762 0.029a    
Resection method
 R1, R2 vs. R0 0.413 1.672–5.041 0.000a    
NOX4 expression in cancer cells
 High vs. low 1.985 1.484–3.592 0.005a    
NOX 4 expression in stroma cells
 High vs. low 1.628 1.389–3.329 0.035a 1.767 1.062–3.942 0.022 a
  1. aP < 0.05, statistically significant; badenocarcinoma, squamous cell carcinoma, adenosquamous carcinoma; HR, Hazard ratio; CI, confidence interval