Skip to main content
Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

Fig. 2

miR-7e-5p is transcriptionally repressed by c-MYC during FL transformation. a Higher levels of miR-7e-5p were detected in WSU-NHL cells after treatment with c-MYC siRNA (50 nM) for 36 h. Cells treated with transfection reagent only served as a negative control (Mock). Statistical test: Mann-Whitney U test. b Real-time PCR revealed the amount of DNA precipitated by anti-c-MYC antibody in WSU-NHL cells. The potential binding site of c-MYC and primers detecting the promoter region are indicated in the scheme. Ch: Chromosome, CAD: Carbamoyl-Phosphate Synthetase-2. Statistical test: Mann-Whitney U test. c Immunohistochemical staining of c-MYC in five paired tissues with FL-tFL transformation. Three representative tissues comparing the expression of c-MYC are shown. Scale bars: 100 μm. d Statistical analysis of c-MYC expression in five paired FL-tFL samples. The percentages of c-MYC-positive cells are shown. Each arrow indicates the change in c-MYC expression in paired samples with transformation. Statistical test: t-test

Back to article page