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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

Fig. 6

FasL increases the apoptosis of M1 cells by binding Fas in patients. a Representative example of HE and IHC stains for Fas and FasL expression in tumor cells in low-grade FL and high-grade FL patient tissues. Original magnification × 400, top right corner × 800. HE: hemotoxylin and eosin staining. Scale bars: 20 μm. b IHC score for Fas and FasL expression levels in tumor cells from eight low-grade FL samples and eight high-grade FL samples. Statistical test: t-test. c Representative example of HE and IHC stains for FasL, CD68, CD163, Caspase3 and Caspase 8 in macrophage cells in low-grade FL and high-grade FL patient tissues. Original magnification × 400, top right corner × 800. Scale bars: 20 μm. d IHC scores for FasL, CD68, CD163, Caspase3 and Caspase 8 expression levels in macrophage cells in eight low-grade FL and eight high-grade FL samples. Statistical test: t-test

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