Fig. 1

Upregulation of UPK1A-AS1 promotes proliferation in HCC cells. a. Results of Gene Set Enrichment Analysis (GSEA)were plotted to visualize the correlation between UPK1A-AS1 and cell cycle gene signatures in HCC sample from TCGA dataset (P < 0.05). b-c. CCK-8 assay was performed to determine the effect of UPK1A-AS1 overexpression on proliferation in SK-Hep-1 (b) and MHCC-97H (c) cells (^**P < 0.01, ^***P < 0.001). d-g. Overexpression of UPK1A-AS1 in SK-Hep-1 (d-e) and MHCC-97H (f-g) cells promoted more cells into S phase than negative control as detected by EdU assay (^*P < 0.05, ^**P < 0.01)