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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Long noncoding RNA UPK1A-AS1 indicates poor prognosis of hepatocellular carcinoma and promotes cell proliferation through interaction with EZH2

Fig. 3

UPK1A-AS1 promotes the G1/S transition of HCC cells. a-d. UPK1A-AS1 increased the ration of cells in S phase in comparison with the negative control in SK-Hep-1 (a-b) and MHCC-97H (c-d) cells (***P < 0.001). Error bars represent the mean ± S.D. of three independent experiments. e. UPK1A-AS1 increased expression of CyclinD1, CDK2, CDK4 and CDK6 in HCC cells by western blotting. f. UPK1A-AS1-overexpressing cells treated with cis-platinum (40 μM) for 24 h. The cells stained with Annexin V-FITC and PI were subjected to FACS analysis. Error bars represent the mean ± S.D. of triplicate experiments (**P < 0.01, ***P < 0.001). h. The expression of caspase-3 and PARP were analyzed using western blottinh in UPK1A-AS1-overexpressing MHCC-97H cells treated with cis-platinum

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