Fig. 3

CD8⁺ T-cell immune function is facilitated by miR-340-5p. a Representative ISH images of the association between miR-340-5p expression and CD8⁺ T-TILs in DLBCL patients. Magnification of the microscope: left column, 40×; right column, 200×. b Schema for coculturing CD8⁺ T cells and DLBCL cells. c-d The representative proportion (c) and cumulative data (d) of CD69^hi cells in CD8⁺ T cells. e-f Cytokine production assays (IFN-γ, TNF-α, and IL-2) were performed for CD8⁺ T cells directly (e) or indirectly (f) cocultured with DLBCL cell lines transfected with m-NC or miR-340-5p. Asterisk (*) indicates a significant difference. *, P < 0.05