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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: MiRNA-340-5p mediates the functional and infiltrative promotion of tumor-infiltrating CD8+ T lymphocytes in human diffuse large B cell lymphoma

Fig. 4

The miR-340-5p/KMT5A axis regulates CD8+ T cells. a Representative IHC images of the association between KMT5A expression and CD8+ T-TILs. Magnification of the microscope: left column, 40Ɨ; right column, 200Ɨ. b KMT5A overexpression was confirmed by western blotting. c Representative example and cumulative data of the virus-specific CD8+ T-cell functional avidity. d Each graph represents cytotoxicity curves for one DLBCL patient. CD8+ T-cell cytotoxicity was quantified with KMT5A-overexpressing or negative control LY-1 cells. Cumulative data of the fold change in cytotoxicity are shown. e KMT5A overexpression significantly reversed the miR-340-5p-induced increase in cytokine production in cocultured CD8+ T cells. Asterisk (*) indicates a significant difference. *, Pā€‰<ā€‰0.05

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