Fig. 6

CD73 ubiquitination is increased by KMT5A knockdown. a GO enrichment analysis. b cAMP signaling pathway enrichment in GSEA. c western blot analysis of CD73 in KMT5A knockdown DLBCL cells. d MG132 rescued KMT5A silencing-induced CD73 downregulation. DLBCL cells transfected with shKMT5A were treated with MG132 or DMSO (control) for 24 h. e Endogenous CD73 stability in LY-1 cells stably overexpressing KMT5A. DLBCL cells were treated with CHX for various time points. f KMT5A silencing promoted CD73 ubiquitination. KMT5A was stably silenced in DLBCL cells. Cells were treated with MG132 for 24 h