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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: MiRNA-340-5p mediates the functional and infiltrative promotion of tumor-infiltrating CD8+ T lymphocytes in human diffuse large B cell lymphoma

Fig. 9

COP1 and APCP exhibited in vivo activity on B-cell lymphoma (a-b) APCP treatment significantly decreased the tumor growth rate in COP1 knockdown cells (a), consistent with Ki-67 expression in IHC analysis b. Statistical tests were performed using tumor volume data on Day 15. c IHC analysis showed that fewer CD8+ T-TILs caused by COP1 knockdown were significantly rescued by APCP treatment. d Representative flow cytometry data and cumulative data for CD8+ T-TILs isolated from murine model tumors. In all experiments, cells were first gated on the CD3+ population and then on the CD8+ population. e Representative flow cytometry data and cumulative data for CD69-positive CD8+ T-TILs. f IHC analysis of granzyme B and perforin Asterisk (*) indicates a significant difference. *, Pā€‰<ā€‰0.05

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