Fig. 9

COP1 and APCP exhibited in vivo activity on B-cell lymphoma (a-b) APCP treatment significantly decreased the tumor growth rate in COP1 knockdown cells (a), consistent with Ki-67 expression in IHC analysis b. Statistical tests were performed using tumor volume data on Day 15. c IHC analysis showed that fewer CD8⁺ T-TILs caused by COP1 knockdown were significantly rescued by APCP treatment. d Representative flow cytometry data and cumulative data for CD8⁺ T-TILs isolated from murine model tumors. In all experiments, cells were first gated on the CD3⁺ population and then on the CD8⁺ population. e Representative flow cytometry data and cumulative data for CD69-positive CD8⁺ T-TILs. f IHC analysis of granzyme B and perforin Asterisk (*) indicates a significant difference. *, P < 0.05