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Fig. 2 | Journal of Experimental & Clinical Cancer Research

Fig. 2

From: Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients

Fig. 2

Poor survival rate of adenocarcinoma and squamous lung cancer patients according to the levels of tumor-tissue caspase-4. a and b Venn’s diagrams obtained by the analysis of genomic alteration on CASP4 (mutation or amplification or higher gene copy number) correlated to other genes involved cell death, inflammation, gene expression and cell proliferation in adenocarcinoma (a) and squamous (b) lung cancer patients by using a public database (www.cbioportal.org). Common genes were related to KRAS, CMYC and CASP5. ROC analyses for caspase-4 and caspase-5 analyzed in samples obtained by adenocarcinoma (n = 66) (c) and squamous (n = 13) (d) patients. Tumor levels of caspase-4 and caspase-5 analysed by means of ELISA were correlated to the available survival rate of (e) adenocarcinoma (n = 53) and (d) squamous (n = 17) NSCLC patients. Median survival of adenocarcinoma patients with high of caspase-4 expression (e, red line) was 0.925 years vs median survival of patients with lower expression (blue line, 3.028 years). Median survival of squamous carcinoma patients with high expression of caspase-4 (f, red line) was 0.864 years vs median survival of patients with lower expression (blue line, not defined). Log-rank Mantel-Cox and Wilcoxon test were performed to statistically analyse the survival rate between the groups

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