Fig. 5
From: The molecular and gene/miRNA expression profiles of radioiodine resistant papillary thyroid cancer
Thyroid differentiation gene expression in PTCs stratified for BRAFV600E mutation and gene fusions. The expression of NIS (SLC5A5), thyroperoxidase (TPO) and pendrin (SLC26A4) genes is shown in PTCs and normal thyroid (NT) samples derived from the present study (a), from GEO dataset GSE27155 (c), from multiple GEO datasets (e) and from TCGA (g). Normalized gene expression values (Log2 scale) are showed for microarray studies (a), (c) and (e); RNAseq normalized expression values (Log2 scale) are showed for TCGA series (g). Thyroid differentiation (TD) score has been calculated for each samples series (b), (d), (f) and (h) as mean expression across the median-centered expression of 16 thyroid function related genes derived from TCGA (see material and methods). Only data for PTC samples with reported BRAV600E mutation or RET or NTRK1 gene fusions are showed. * p-value < 0.05 ** p-value < 0.005; *** p-value < 0.0001 by Mann-Whitney test