Fig. 8

CircMCTP2 sensitizes GC cells to CDDP in vivo. a-d CircMCTP2 suppressed the growth of xenograft tumors with CDDP treatment. e Xenograft tumor weights were measured. f CircMCTP2 expression was detected by qRT-PCR in xenograft tumors. g The percentage of Ki67-positive cells in xenograft tumors was measured. h TUNEL assay was performed to determine the apoptosis of GC cells in nude mouse tumors. i, j MTMR3 protein expression in xenograft tumors was examined by IHC and western blotting. k The expression levels of circMCTP2 and miR-99a-5p were detected by FISH assay in CDDP-resistant and CDDP-sensitive GC tissues. l The results of IHC revealed that MTMR3 was downregulated in CDDP-resistant GC tissues. (*p < 0.05, **p < 0.01. Data are expressed as the means ± SDs)