Inhibition of SIRT6 potentiates the anti-tumor effect of doxorubicin through suppression of the DNA damage repair pathway in osteosarcoma

Table 1 The clinical characteristics of 27 osteosarcomas and their correlation with the immunohistochemical expression of SIRT6

Characteristics		No.	SIRT6
			Positive	P
Age, years	< 30	24	11 (46%)	0.642
	≥ 30	13	7 (54%)
Sex	Male	25	13 (52%)	0.556
	Female	12	5 (42%)
Tumor size	≤ 8 cm	19	9 (47%)	0.873
	> 8 cm	18	9 (50%)
Stage	I	11	4 (36%)	0.331
	II, III, & IV	26	14 (54%)
Histologic grade	1 & 2	10	3 (30%)	0.167
	3 & 4	27	15 (56%)
Lymph node metastasis	Absence	34	17 (50%)	0.580
	Presence	3	1 (33%)
Distant metastasis at diagnosis	Absence	30	14 (47%)	0.618
	Presence	7	4 (57%)
Latent distant metastasis	Absence	28	10 (36%)	0.005
	Presence	9	8 (89%)

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