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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Fig. 1

Expression of LAT1 in tumor-associated vascular endothelial cells. a Immunohistochemistry of LAT1 and CD31 in pancreatic ductal adenocarcinoma (PDA) and normal pancreas. Representative images from CU1372–35-35,006 (PDA) and CU2009/02 X-40 (normal pancreas) are shown. Arrows and arrowheads indicate tumor cells and endothelial cells, respectively. Black squares; enlarged images. b Immunofluorescence of LAT1 (green) and CD31 (purple) in PDA and normal pancreas. Nuclei stained with DAPI (blue) are shown in the merged images. c Endothelial LAT1 expression in tissue microarray containing PDA and normal pancreas. Tissues spots were classified depending on the LAT1 staining intensity in endothelial cells: High, Low/Medium, and Negative. Data shown are the percentage of each group. d and e Immunohistochemistry of mouse LAT1 and CD34 in paraffin sections of MIA PaCa-2 (d) and H520 (e) xenograft tumors. Arrowheads indicate endothelial cells. Black squares; enlarged images. Mouse LAT1 was visualized with mouse-specific mLAT1(c) antibody (LAT1(Ms))

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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