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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Amino acid transporter LAT1 in tumor-associated vascular endothelium promotes angiogenesis by regulating cell proliferation and VEGF-A-dependent mTORC1 activation

Fig. 3

Suppression of endothelial sprouting in aortic ring assay by genetic ablation of LAT1. a LAT1 mRNA expression in Matrigel-embedded aortic rings of Lat1fl/fl/rtTA3/TetO-Cre mice analyzed on the day of embedding (Day 0) and three days later (Day 3), with or without DOX-treatment. b Aortic ring assay using Lat1fl/fl/rtTA3/TetO-Cre mice and control littermates (Lat1fl/fl/rtTA3 and Lat1fl/fl/TetO-Cre). c LAT1 mRNA expression in aortic rings of Lat1fl/fl/Tek-Cre mice and control littermates (Lat1fl/fl) analyzed on Day 0 and Day 3. d Aortic ring assay using Lat1fl/fl/Tek-Cre and Lat1fl/fl mice. b, d Bar graphs; quantification of endothelial sprouts. a, c, n = 4; b, n = 5; d, n = 8

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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