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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications

Fig. 3

The microenvironment of pancreatic cancer. The stroma consists of cellular components (including immune cells, PSCs, CAFs and cancer cells) and noncellular components (hyaluronic acid, collagen, capillaries and fibronectin). This compact tissue lacking feeding vessels to provide nutrition blocks the diffusion of oxygen and transportation of glucose. In this situation, cells away from the vessels start to convert into glycolytic types. The dense stroma also contributes to chemo/radiotherapy resistance to drugs and resistance to T cells. There is a heated debate on the concrete function of the dense stroma: does it provide more benefits than disadvantages in PDAC? It is worth expending more efforts to unravel this mystery

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