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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Glycometabolic rearrangements--aerobic glycolysis in pancreatic cancer: causes, characteristics and clinical applications

Fig. 4

Interaction between a PSC and PDAC cell. Reverse Warburg effect: PSCs utilize glucose to conduct glycolysis and produce pyruvate and lactate, which can enter PDAC cells and undergo mitochondrial respiration to produce energy. The metabolites of glycolysis in PSCs can be transported into pancreatic cancer cells for oxidative phosphorylation via MCT-4 and MCT-1. ROS generated by pancreatic cancer cells then spread into PSCs, inducing an increase in HIF-1α expression to further augment glycolysis in the PSCs. Exosomes secreted by PSCs containing gene products and lipids are internalized by pancreatic cancer cells. This interaction plays a vital role in the progression of pancreatic cancer and contributes to immune escape

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