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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Fig. 3

miR-1185-2-3p directly inhibits the expression of GOLPH3L and suppresses tumorigenic activities. a miR-1185-2-3p targeted the predicted sites within the 3′-UTR of GOLPH3L, and mutation of the predicted target sites rescued the inhibitory effects of miR-1185-2-3p; n = 3, * p < 0.05, ** p < 0.01. b The comparison of the levels of miR-1185-2-3p in human breast cancers (n = 101) and tumor-adjacent normal tissues (n = 15) with GSE45666 (left panel). Log-rank (Mantel Cox) test of breast cancer patient survival based on the levels of miR-1185-2-3p (low expression n = 868, high expression n = 394); p-values are indicated (middle panel). The expression of miR-1185-2-3p was significantly reduced in various breast cancer cells; n = 3, ** p < 0.01 (right panel). c Inhibition and overexpression of miR-1185-2-3p inversely correlated with the levels of GOLPH3L mRNA (top panel) and protein (bottom panel); n = 3, ** p < 0.01. d Overexpression of miR-1185-2-3p reduced the proliferation of T47D cells; n = 3, ** p < 0.01. e miR-1185-2-3p overexpression significantly induced apoptosis in T47D cells; n = 3, ** p < 0.01. f Overexpression of miR-1185-2-3p reduced the migration of T47D cells; n = 3, ** p < 0.01. g Overexpression of miR-1185-2-3p blocked the cell cycle at G0/G1 phase; n = 3, ** p < 0.01

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