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Table 1 Metabolites that were altered significantly after GOLPH3L silencing

From: The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Name

ID

VIP

Fold change

p-value

M348T450

Adenosine monophosphate (AMP)

5.35017309

0.343953619

1.85022E-09

M489T438

Cytidine 5′-diphosphocholine (CDP-choline)

3.769023161

0.294683065

2.09147E-09

M325T436

Uridine 5′-monophosphate (UMP)

2.859910755

0.36416908

1.85344E-08

M136T425

Adenine

3.624555449

0.541578913

3.52988E-08

M216T387

sn-Glycerol 3-phosphoethanolamine

3.817810077

0.662660731

1.64313E-07

M113T160

Uracil

2.339930939

0.254999039

2.66289E-07

M162T355_2

L-carnitine

2.259917766

0.687860774

5.55508E-07

M244T235

Cytidine

1.320380286

0.343617832

6.16343E-07

M664T430

Nicotinamide adenine dinucleotide (NAD)

5.426903613

0.531267518

6.8003E-07

M204T426

N-acetyl-D-glucosamine

2.162566187

0.585855735

6.80877E-07

M268T167

Adenosine

2.080090077

0.506337679

8.19558E-07

M152T457

2-Hydroxyadenine

1.192073219

0.418366736

1.00101E-06

M364T457

Guanosine 5′-monophosphate (GMP)

2.20531908

0.381298814

1.34425E-06

M598T474

Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate)

1.241389474

0.627904863

2.896E-06

M810T418

Acetyl coenzyme A (Acetyl-CoA)

1.148074386

0.537400888

7.08625E-06

M148T391

L-glutamate

3.853584751

0.737242788

8.94063E-06

M584T438

UDP-D-galactose

1.033843982

0.641425356

9.98778E-06

M137T166

Hypoxanthine

6.446185931

0.11746834

1.93784E-05

M428T452_2

Adenosine 5′-diphosphate (ADP)

7.163025043

0.57751916

2.09404E-05

M447T442

CDP-ethanolamine

1.026217107

0.611693587

2.16949E-05

M291T464

Argininosuccinic acid

1.026399168

1.525518377

2.31077E-05

M188T257

DL-indole-3-lactic acid

1.240956561

0.489217809

2.34219E-05

M102T391

1-Aminocyclopropanecarboxylic acid

1.410081315

0.756256635

2.38876E-05

M246T242

2-Methylbutyroylcarnitine

7.369334193

0.509326233

3.52739E-05

M106T299

Diethanolamine

1.53304285

14.44114449

3.92078E-05

M245T409

Pro-Glu

1.083816026

0.642279716

4.4156E-05

M316T193

Decanoyl-L-carnitine

1.705457563

0.620089802

8.50963E-05

M204T303

Acetylcarnitine

10.77036712

0.725339373

0.000102368

M422T466

Uridine 5′-diphosphate (UDP)

1.109528766

0.668781099

0.000142935

M400T159_2

L-palmitoylcarnitine

8.34588634

0.644174553

0.000177908

M147T369

L-pyroglutamic acid

1.765274591

1.542951135

0.000179981

M233T395

Gamma-glutamylcysteine

1.388401872

0.540837694

0.000320962

M112T236

Cytosine

1.593691839

0.555964705

0.000415561

M542T430

ADP-ribose

1.028412857

0.622601002

0.00064559

M308T428

Glutathione

4.266509616

0.504989177

0.000716522

M123T61

Nicotinamide

1.851347574

0.566997397

0.000943254

M156T441

L-histidine

1.2602915

1.504208252

0.00100569

M170T397

3-Methyl-L-histidine

2.097791259

7.382253419

0.001046756

M120T256

Tyramine

1.693843786

0.657319643

0.001442055

M166T256

L-phenylalanine

1.120111864

0.675428936

0.002216965

M146T374_2

(3-Carboxypropyl) trimethylammonium cation

3.995126207

0.750604189

0.002386475

M132T263

L-leucine

1.432367955

0.424002729

0.002807843

M179T427

Cys-Gly

1.127437605

0.643923687

0.006537627

M258T457

Glycerophosphocholine

1.162325024

0.70923693

0.018142168

M508T581

Adenosine 5′-triphosphate (ATP)

1.252149198

0.44136226

0.018216171

M391T33

Dioctyl phthalate

5.057833924

0.806525311

0.019249997

M613T491

Glutathione disulfide

2.467281297

0.722876989

0.059115948

M468T200

1-Myristoyl-sn-glycero-3-phosphocholine

1.668722344

2.054758707

0.059687763

M118T462

Betaine

2.078707794

1.308639016

0.05975974

M184T566

Phosphorylcholine

1.969089209

0.217723196

0.060512883

M496T166

1-Palmitoyl-sn-glycero-3-phosphocholine

3.467532932

1.405433036

0.060816012

M203T505

NG,NG-dimethyl-L-arginine (ADMA)

1.02231111

0.612169445

0.079805836

M130T542

D-pipecolinic acid

1.22345702

0.462637578

0.081203784

M279T33

Phthalic acid mono-2-ethylhexyl ester

2.038184914

0.869293803

0.088733314

M341T395

maltose

2.111953392

0.028561128

3.10543E-17

M347T439

Inosine 5′-monophosphate (IMP)

3.625592991

0.301881382

6.71817E-16

M322T450

Cytidine 5′-monophosphate (CMP)

1.192275542

0.62674391

2.23826E-14

M662T429

Nicotinamide adenine dinucleotide (NAD)

5.135975169

0.567384075

4.63725E-13

M547T437

Cytidine 5′-diphosphocholine (CDP-choline)

1.791062321

0.406528182

1.40724E-12

M362T455

Guanosine 5′-monophosphate (GMP)

3.653583959

0.407242856

4.41861E-12

M540T428

Cyclic adenosine diphosphate ribose

4.068411598

0.566724985

6.8843E-12

M606T424

UDP-N-acetylglucosamine

18.47592875

0.611830043

7.85683E-12

M323T434

Uridine 5′-monophosphate (UMP)

7.171175055

0.404982084

1.33639E-11

M346T422

Adenosine monophosphate (AMP)

14.34548448

0.318588959

2.04199E-11

M203T254

L-tryptophan

2.120508327

0.500782842

3.29102E-11

M214T388

sn-Glycerol 3-phosphoethanolamine

9.759185833

0.725105379

3.90018E-11

M242T234

Cytidine

1.768227149

0.351697024

1.48152E-10

M445T440

CDP-ethanolamine

2.832548838

0.60943293

2.32647E-10

M808T416

Acetyl coenzyme A (acetyl-CoA)

1.321582442

0.559526257

3.85093E-10

M742T485

Nicotinamide adenine dinucleotide phosphate (NADP)

1.711544078

0.624512533

8.56497E-10

M130T260

L-Isoleucine

3.729655739

0.588743745

1.07604E-09

M613T434

Cytidine monophosphate N-acetylneuraminic acid

3.365736279

0.515824367

1.14679E-09

M171T383

Glycerol 3-phosphate

3.123463887

0.690487464

1.17292E-09

M147T385

(S)-2-Hydroxyglutarate

2.209506147

0.672217978

1.29056E-09

M167T451

Phosphoenolpyruvate

3.418641375

1.879691109

1.38673E-09

M174T387_2

N-Acetyl-L-aspartic acid

5.248401418

0.659295634

2.85219E-09

M258T410

D-Glucosamine 1-phosphate (glucosamine-1P)

1.215448728

0.595730278

2.98007E-09

M135T165

Hypoxanthine

2.83515564

0.155797031

3.3521E-09

M565T436

Uridine diphosphate glucose (UDP-D-glucose)

4.94082239

0.593931258

5.65669E-09

M239T387

D-Mannose

1.267493145

0.837341404

1.65544E-08

M131T253

Ethylmalonic acid

1.942789906

0.670553701

2.25702E-08

M182T474

Phosphorylcholine

1.592146407

0.776441511

5.19225E-08

M426T481

Adenosine 5′-diphosphate (ADP)

2.142482016

0.786728943

6.27755E-08

M403T463

Uridine 5′-diphosphate (UDP)

6.023335277

0.590303313

6.92096E-08

M164T253

L-phenylalanine

2.745272587

0.649759377

1.09694E-07

M128T370_1

L-pyroglutamic acid

1.084478181

1.326574096

1.35422E-07

M259T448

Alpha-D-glucose 1-phosphate

1.955748269

1.727049692

6.43531E-07

M303T435

N-acetylaspartylglutamate (NAAG)

1.092531363

0.622574707

1.04037E-06

M145T372

L-glutamine

4.84006701

1.691397723

1.33369E-06

M117T380_2

Succinate

3.22018177

0.745112292

1.33821E-06

M146T390_2

L-glutamate

6.383368133

0.805813766

1.34212E-06

M111T83

Uracil

4.093084571

0.338717051

1.98724E-06

M255T38

Palmitic acid

15.91857778

1.482478443

2.63587E-06

M462T486

Adenylsuccinic acid

1.400896234

0.601445092

3.04252E-06

M179T387_2

Myo-Inositol

1.869509045

0.876085103

3.53295E-06

M588T446

GDP-L-fucose

1.036473053

0.727980689

3.8859E-06

M458T140

L-palmitoylcarnitine

1.71058671

0.69922387

3.95794E-06

M296T70

S-methyl-5′-thioadenosine

2.695515248

0.562035793

5.0904E-06

M114T308

L-Proline

1.492638552

0.844853133

6.29786E-06

M130T386

N-acetyl-L-alanine

1.284618775

0.714233544

7.07193E-06

M611T488

Glutathione disulfide

6.326051929

0.673543892

2.60415E-05

M89T221_2

DL-lactate

6.180555782

0.771109869

3.15076E-05

M506T481

Adenosine 5′-triphosphate (ATP)

6.265508138

0.776594367

7.93354E-05

M133T396

L-malic acid

3.710482706

0.870781902

0.00015885

M306T394

Glutathione

6.846802373

0.645572726

0.000202429

M452T199

1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine

2.364541907

1.17565739

0.000288876

M281T38

Oleic acid

10.56865128

1.261282292

0.000386302

M337T38

Erucic acid

1.462001645

0.804834608

0.000563427

M483T490

Uridine 5′-triphosphate (UTP)

2.985361942

0.791767071

0.000765923

M673T189

1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate

1.958401653

1.956770427

0.001001254

M253T38

Cis-9-palmitoleic acid

3.035713741

1.176091575

0.004203955

M227T150

Myristic acid

1.009572648

1.48607569

0.004811555

M197T38

3-Hydroxydodecanoic acid

2.666768268

0.71831232

0.006944812

M333T125

Penicillin G

1.82556849

0.584544716

0.009905013

M273T34

Salicylamide

1.383050648

0.362734521

0.009978679

M579T469

Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate)

3.315658544

0.86375998

0.010231094

M141T353

2-Oxoadipic acid

11.40052894

0.912787301

0.015048419

M130T344

Creatine

1.009533641

0.795141329

0.017407461

M154T411

Urocanic acid

1.176119208

1.475399848

0.020677476

M173T432

Cis-Aconitate

1.169850112

0.768659387

0.021442597

M219T2

4-Nonylphenol

2.042585348

1.263228143

0.043438355

M134T153

Adenine

1.249418803

0.62240901

0.043527968

M269T136

Heptadecanoic acid

1.030910387

0.689149164

0.05747134

M131T375

L-asparagine

1.700684605

1.62285133

0.061339629

M191T497

Citrate

2.212863083

0.850809508

0.067218448

M181T296

D-threitol

1.061736173

0.563835355

0.079699611

  1. Legend: Untargeted metabolomics sequencing was used to reveal metabolites that were altered significantly after GOLPH3L silencing, and those with p-values< 0.05 are indicated