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Table 1 Metabolites that were altered significantly after GOLPH3L silencing

From: The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Name ID VIP Fold change p-value
M348T450 Adenosine monophosphate (AMP) 5.35017309 0.343953619 1.85022E-09
M489T438 Cytidine 5′-diphosphocholine (CDP-choline) 3.769023161 0.294683065 2.09147E-09
M325T436 Uridine 5′-monophosphate (UMP) 2.859910755 0.36416908 1.85344E-08
M136T425 Adenine 3.624555449 0.541578913 3.52988E-08
M216T387 sn-Glycerol 3-phosphoethanolamine 3.817810077 0.662660731 1.64313E-07
M113T160 Uracil 2.339930939 0.254999039 2.66289E-07
M162T355_2 L-carnitine 2.259917766 0.687860774 5.55508E-07
M244T235 Cytidine 1.320380286 0.343617832 6.16343E-07
M664T430 Nicotinamide adenine dinucleotide (NAD) 5.426903613 0.531267518 6.8003E-07
M204T426 N-acetyl-D-glucosamine 2.162566187 0.585855735 6.80877E-07
M268T167 Adenosine 2.080090077 0.506337679 8.19558E-07
M152T457 2-Hydroxyadenine 1.192073219 0.418366736 1.00101E-06
M364T457 Guanosine 5′-monophosphate (GMP) 2.20531908 0.381298814 1.34425E-06
M598T474 Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) 1.241389474 0.627904863 2.896E-06
M810T418 Acetyl coenzyme A (Acetyl-CoA) 1.148074386 0.537400888 7.08625E-06
M148T391 L-glutamate 3.853584751 0.737242788 8.94063E-06
M584T438 UDP-D-galactose 1.033843982 0.641425356 9.98778E-06
M137T166 Hypoxanthine 6.446185931 0.11746834 1.93784E-05
M428T452_2 Adenosine 5′-diphosphate (ADP) 7.163025043 0.57751916 2.09404E-05
M447T442 CDP-ethanolamine 1.026217107 0.611693587 2.16949E-05
M291T464 Argininosuccinic acid 1.026399168 1.525518377 2.31077E-05
M188T257 DL-indole-3-lactic acid 1.240956561 0.489217809 2.34219E-05
M102T391 1-Aminocyclopropanecarboxylic acid 1.410081315 0.756256635 2.38876E-05
M246T242 2-Methylbutyroylcarnitine 7.369334193 0.509326233 3.52739E-05
M106T299 Diethanolamine 1.53304285 14.44114449 3.92078E-05
M245T409 Pro-Glu 1.083816026 0.642279716 4.4156E-05
M316T193 Decanoyl-L-carnitine 1.705457563 0.620089802 8.50963E-05
M204T303 Acetylcarnitine 10.77036712 0.725339373 0.000102368
M422T466 Uridine 5′-diphosphate (UDP) 1.109528766 0.668781099 0.000142935
M400T159_2 L-palmitoylcarnitine 8.34588634 0.644174553 0.000177908
M147T369 L-pyroglutamic acid 1.765274591 1.542951135 0.000179981
M233T395 Gamma-glutamylcysteine 1.388401872 0.540837694 0.000320962
M112T236 Cytosine 1.593691839 0.555964705 0.000415561
M542T430 ADP-ribose 1.028412857 0.622601002 0.00064559
M308T428 Glutathione 4.266509616 0.504989177 0.000716522
M123T61 Nicotinamide 1.851347574 0.566997397 0.000943254
M156T441 L-histidine 1.2602915 1.504208252 0.00100569
M170T397 3-Methyl-L-histidine 2.097791259 7.382253419 0.001046756
M120T256 Tyramine 1.693843786 0.657319643 0.001442055
M166T256 L-phenylalanine 1.120111864 0.675428936 0.002216965
M146T374_2 (3-Carboxypropyl) trimethylammonium cation 3.995126207 0.750604189 0.002386475
M132T263 L-leucine 1.432367955 0.424002729 0.002807843
M179T427 Cys-Gly 1.127437605 0.643923687 0.006537627
M258T457 Glycerophosphocholine 1.162325024 0.70923693 0.018142168
M508T581 Adenosine 5′-triphosphate (ATP) 1.252149198 0.44136226 0.018216171
M391T33 Dioctyl phthalate 5.057833924 0.806525311 0.019249997
M613T491 Glutathione disulfide 2.467281297 0.722876989 0.059115948
M468T200 1-Myristoyl-sn-glycero-3-phosphocholine 1.668722344 2.054758707 0.059687763
M118T462 Betaine 2.078707794 1.308639016 0.05975974
M184T566 Phosphorylcholine 1.969089209 0.217723196 0.060512883
M496T166 1-Palmitoyl-sn-glycero-3-phosphocholine 3.467532932 1.405433036 0.060816012
M203T505 NG,NG-dimethyl-L-arginine (ADMA) 1.02231111 0.612169445 0.079805836
M130T542 D-pipecolinic acid 1.22345702 0.462637578 0.081203784
M279T33 Phthalic acid mono-2-ethylhexyl ester 2.038184914 0.869293803 0.088733314
M341T395 maltose 2.111953392 0.028561128 3.10543E-17
M347T439 Inosine 5′-monophosphate (IMP) 3.625592991 0.301881382 6.71817E-16
M322T450 Cytidine 5′-monophosphate (CMP) 1.192275542 0.62674391 2.23826E-14
M662T429 Nicotinamide adenine dinucleotide (NAD) 5.135975169 0.567384075 4.63725E-13
M547T437 Cytidine 5′-diphosphocholine (CDP-choline) 1.791062321 0.406528182 1.40724E-12
M362T455 Guanosine 5′-monophosphate (GMP) 3.653583959 0.407242856 4.41861E-12
M540T428 Cyclic adenosine diphosphate ribose 4.068411598 0.566724985 6.8843E-12
M606T424 UDP-N-acetylglucosamine 18.47592875 0.611830043 7.85683E-12
M323T434 Uridine 5′-monophosphate (UMP) 7.171175055 0.404982084 1.33639E-11
M346T422 Adenosine monophosphate (AMP) 14.34548448 0.318588959 2.04199E-11
M203T254 L-tryptophan 2.120508327 0.500782842 3.29102E-11
M214T388 sn-Glycerol 3-phosphoethanolamine 9.759185833 0.725105379 3.90018E-11
M242T234 Cytidine 1.768227149 0.351697024 1.48152E-10
M445T440 CDP-ethanolamine 2.832548838 0.60943293 2.32647E-10
M808T416 Acetyl coenzyme A (acetyl-CoA) 1.321582442 0.559526257 3.85093E-10
M742T485 Nicotinamide adenine dinucleotide phosphate (NADP) 1.711544078 0.624512533 8.56497E-10
M130T260 L-Isoleucine 3.729655739 0.588743745 1.07604E-09
M613T434 Cytidine monophosphate N-acetylneuraminic acid 3.365736279 0.515824367 1.14679E-09
M171T383 Glycerol 3-phosphate 3.123463887 0.690487464 1.17292E-09
M147T385 (S)-2-Hydroxyglutarate 2.209506147 0.672217978 1.29056E-09
M167T451 Phosphoenolpyruvate 3.418641375 1.879691109 1.38673E-09
M174T387_2 N-Acetyl-L-aspartic acid 5.248401418 0.659295634 2.85219E-09
M258T410 D-Glucosamine 1-phosphate (glucosamine-1P) 1.215448728 0.595730278 2.98007E-09
M135T165 Hypoxanthine 2.83515564 0.155797031 3.3521E-09
M565T436 Uridine diphosphate glucose (UDP-D-glucose) 4.94082239 0.593931258 5.65669E-09
M239T387 D-Mannose 1.267493145 0.837341404 1.65544E-08
M131T253 Ethylmalonic acid 1.942789906 0.670553701 2.25702E-08
M182T474 Phosphorylcholine 1.592146407 0.776441511 5.19225E-08
M426T481 Adenosine 5′-diphosphate (ADP) 2.142482016 0.786728943 6.27755E-08
M403T463 Uridine 5′-diphosphate (UDP) 6.023335277 0.590303313 6.92096E-08
M164T253 L-phenylalanine 2.745272587 0.649759377 1.09694E-07
M128T370_1 L-pyroglutamic acid 1.084478181 1.326574096 1.35422E-07
M259T448 Alpha-D-glucose 1-phosphate 1.955748269 1.727049692 6.43531E-07
M303T435 N-acetylaspartylglutamate (NAAG) 1.092531363 0.622574707 1.04037E-06
M145T372 L-glutamine 4.84006701 1.691397723 1.33369E-06
M117T380_2 Succinate 3.22018177 0.745112292 1.33821E-06
M146T390_2 L-glutamate 6.383368133 0.805813766 1.34212E-06
M111T83 Uracil 4.093084571 0.338717051 1.98724E-06
M255T38 Palmitic acid 15.91857778 1.482478443 2.63587E-06
M462T486 Adenylsuccinic acid 1.400896234 0.601445092 3.04252E-06
M179T387_2 Myo-Inositol 1.869509045 0.876085103 3.53295E-06
M588T446 GDP-L-fucose 1.036473053 0.727980689 3.8859E-06
M458T140 L-palmitoylcarnitine 1.71058671 0.69922387 3.95794E-06
M296T70 S-methyl-5′-thioadenosine 2.695515248 0.562035793 5.0904E-06
M114T308 L-Proline 1.492638552 0.844853133 6.29786E-06
M130T386 N-acetyl-L-alanine 1.284618775 0.714233544 7.07193E-06
M611T488 Glutathione disulfide 6.326051929 0.673543892 2.60415E-05
M89T221_2 DL-lactate 6.180555782 0.771109869 3.15076E-05
M506T481 Adenosine 5′-triphosphate (ATP) 6.265508138 0.776594367 7.93354E-05
M133T396 L-malic acid 3.710482706 0.870781902 0.00015885
M306T394 Glutathione 6.846802373 0.645572726 0.000202429
M452T199 1-Palmitoyl-2-hydroxy-sn-glycero-3-phosphoethanolamine 2.364541907 1.17565739 0.000288876
M281T38 Oleic acid 10.56865128 1.261282292 0.000386302
M337T38 Erucic acid 1.462001645 0.804834608 0.000563427
M483T490 Uridine 5′-triphosphate (UTP) 2.985361942 0.791767071 0.000765923
M673T189 1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphate 1.958401653 1.956770427 0.001001254
M253T38 Cis-9-palmitoleic acid 3.035713741 1.176091575 0.004203955
M227T150 Myristic acid 1.009572648 1.48607569 0.004811555
M197T38 3-Hydroxydodecanoic acid 2.666768268 0.71831232 0.006944812
M333T125 Penicillin G 1.82556849 0.584544716 0.009905013
M273T34 Salicylamide 1.383050648 0.362734521 0.009978679
M579T469 Uridine 5′-diphosphoglucuronic acid (UDP-D-glucuronate) 3.315658544 0.86375998 0.010231094
M141T353 2-Oxoadipic acid 11.40052894 0.912787301 0.015048419
M130T344 Creatine 1.009533641 0.795141329 0.017407461
M154T411 Urocanic acid 1.176119208 1.475399848 0.020677476
M173T432 Cis-Aconitate 1.169850112 0.768659387 0.021442597
M219T2 4-Nonylphenol 2.042585348 1.263228143 0.043438355
M134T153 Adenine 1.249418803 0.62240901 0.043527968
M269T136 Heptadecanoic acid 1.030910387 0.689149164 0.05747134
M131T375 L-asparagine 1.700684605 1.62285133 0.061339629
M191T497 Citrate 2.212863083 0.850809508 0.067218448
M181T296 D-threitol 1.061736173 0.563835355 0.079699611
  1. Legend: Untargeted metabolomics sequencing was used to reveal metabolites that were altered significantly after GOLPH3L silencing, and those with p-values< 0.05 are indicated
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