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Table 2 KEGG pathway analysis of different metabolites that were altered significantly after GOLPH3L silencing

From: The miR-1185-2-3p—GOLPH3L pathway promotes glucose metabolism in breast cancer by stabilizing p53-induced SERPINE1

Map-ID Map name Ref_ per P-value FDR Rich factor
map 05230 Central carbon metabolism in cancer 0.902218971 1.52023E-15 1.9611E-13 0.378378378
map 00250 Alanine, aspartate and glutamate metabolism 0.682760302 1.32499E-09 8.54619E-08 0.321428571
map 02010 ABC transporters 3.340648622 4.36608E-09 1.6293E-07 0.116788321
map 00010 Glycolysis/Gluconeogenesis 0.780297488 5.05208E-09 1.6293E-07 0.28125
map 04974 Protein digestion and absorption 1.146061936 1.30029E-08 3.35475E-07 0.212765957
map 00970 Aminoacyl-tRNA biosynthesis 1.267983419 4.83446E-07 1.03941E-05 0.173076923
map 01230 Biosynthesis of amino acids 3.121189954 7.70926E-07 1.42071E-05 0.1015625
map 04978 Mineral absorption 0.707144599 9.11103E-07 1.46915E-05 0.24137931
map 00020 Citrate cycle (TCA cycle) 0.48768593 1.42224E-06 2.03854E-05 0.3
map 00230 Purine metabolism 2.316508169 1.61025E-06 2.07723E-05 0.115789474
map 00240 Pyrimidine metabolism 1.584979273 3.42162E-06 4.01262E-05 0.138461538
map 04080 Neuroactive ligand-receptor interaction 1.267983419 5.53193E-06 5.94683E-05 0.153846154
map 00480 Glutathione metabolism 0.926603267 6.39595E-06 6.34675E-05 0.184210526
map 04922 Glucagon signaling pathway 0.633991709 7.69409E-06 7.08956E-05 0.230769231
map 04142 Lysosome 0.097537186 2.8207E-05 0.00024258 0.75
map 00520 Amino sugar and nucleotide sugar metabolism 2.633504023 3.71809E-05 0.000299771 0.092592593
map 05231 Choline metabolism in cancer 0.268227262 3.99483E-05 0.000303137 0.363636364
map 00564 Glycerophospholipid metabolism 1.267983419 5.44277E-05 0.000390065 0.134615385
map 04068 FoxO signaling pathway 0.121921483 6.95244E-05 0.000472034 0.6
map 01100 Metabolic pathways 65.88636918 9.23119E-05 0.000595411 0.025166543
map 00630 Glyoxylate and dicarboxylate metabolism 1.511826384 0.000171042 0.001050688 0.112903226
map 00190 Oxidative phosphorylation 0.390148744 0.000204512 0.001149292 0.25
map 04216 Ferroptosis 0.707144599 0.000204912 0.001149292 0.172413793
map 04924 Renin secretion 0.414533041 0.00026349 0.001359611 0.235294118
map 04964 Proximal tubule bicarbonate reclamation 0.414533041 0.00026349 0.001359611 0.235294118
map 04931 Insulin resistance 0.463301634 0.000416546 0.00206671 0.210526316
map 05012 Parkinson disease 0.48768593 0.000513007 0.002451034 0.2
map 04727 GABAergic synapse 0.219458669 0.000551859 0.002542494 0.333333333
map 04152 AMPK signaling pathway 0.536454523 0.000751888 0.00334244 0.181818182
map 04022 cGMP-PKG signaling pathway 0.243842965 0.000777312 0.00334244 0.3
map 04714 Thermogenesis 0.56083882 0.000896782 0.003731772 0.173913043
map 00052 Galactose metabolism 1.12167764 0.001825222 0.007357924 0.108695652
map 04150 mTOR signaling pathway 0.097537186 0.002198433 0.008593874 0.5
map 00620 Pyruvate metabolism 0.755913192 0.002830833 0.010740513 0.129032258
map 05131 Shigellosis 0.390148744 0.003333451 0.012286147 0.1875
map 01523 Antifolate resistance 0.414533041 0.003991299 0.014302156 0.176470588
map 01210 2-Oxocarboxylic acid metabolism 3.267495733 0.004212296 0.014686113 0.059701493
map 00061 Fatty acid biosynthesis 1.414289198 0.00508542 0.017263662 0.086206897
map 04918 Thyroid hormone synthesis 0.512070227 0.007380826 0.024413503 0.142857143
map 04925 Aldosterone synthesis and secretion 0.536454523 0.008427501 0.02717869 0.136363636
map 00290 Valine, leucine and isoleucine biosynthesis 0.56083882 0.009557109 0.027345439 0.130434783
map 00220 Arginine biosynthesis 0.56083882 0.009557109 0.027345439 0.130434783
map 04724 Glutamatergic synapse 0.195074372 0.009751087 0.027345439 0.25
map 04211 Longevity regulating pathway 0.195074372 0.009751087 0.027345439 0.25
map 04740 Olfactory transduction 0.195074372 0.009751087 0.027345439 0.25
map 05032 Morphine addiction 0.195074372 0.009751087 0.027345439 0.25
map 04024 cAMP signaling pathway 0.609607413 0.012070106 0.033128589 0.12
map 05034 Alcoholism 0.243842965 0.015279969 0.041064916 0.2
map 00310 Lysine degradation 1.316752012 0.020299998 0.053442852 0.074074074
map 00760 Nicotinate and nicotinamide metabolism 1.341136308 0.021575257 0.054211054 0.072727273
map 04742 Taste transduction 0.755913192 0.021700254 0.054211054 0.096774194
map 04721 Synaptic vesicle cycle 0.292611558 0.021852518 0.054211054 0.166666667
map 01200 Carbon metabolism 2.779809802 0.022892225 0.055718812 0.052631579
map 00410 Beta-alanine metabolism 0.780297488 0.023615333 0.056414406 0.09375
map 00471 D-Glutamine and D-glutamate metabolism 0.316995855 0.025502823 0.059815712 0.153846154
map 00400 Phenylalanine, tyrosine and tryptophan biosynthesis 0.829066081 0.027712438 0.06383758 0.088235294
map 04611 Platelet activation 0.341380151 0.029381868 0.065349326 0.142857143
map 04923 Regulation of lipolysis in adipocytes 0.341380151 0.029381868 0.065349326 0.142857143
map 04066 HIF-1 signaling pathway 0.365764448 0.033479574 0.073201103 0.133333333
map 00500 Starch and sucrose metabolism 0.902218971 0.034522413 0.074223189 0.081081081
map 00561 Glycerolipid metabolism 0.926603267 0.036968063 0.078178362 0.078947368
map 00280 Valine, leucine and isoleucine degradation 1.024140454 0.047613224 0.097493744 0.071428571
map 00650 Butanoate metabolism 1.024140454 0.047613224 0.097493744 0.071428571
  1. Legend: KEGG pathways of different metabolites that were altered significantly after GOLPH3L silencing, p-values< 0.05
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