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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Mitophagy promotes sorafenib resistance through hypoxia-inducible ATAD3A dependent Axis

Fig. 6

The miR-210-5P-ATAD3A axis influences xenografts formation in vivo. a Representative images of ATAD3A expression with IHC staining in hepatocellular carcinoma specimens. b Representative images of ATAD3A expression with IHC staining in tumor and adjacent hepatocellular carcinoma specimens. c Statistical analysis of IHC-determined ATAD3A expression in tumor and adjacent normal tissue from HCC patients (Student t test) (n = 85). d Comparison of IHC-determined ATAD3A expression among HCC patients of different pathological grades. e Percentages of strong, moderate, and negative ATAD3A expression in hepatocellular carcinoma samples(n = 135). f Kaplan-Meier analysis of ATAD3A expression and overall survival of HCC patients(n = 135). g Immunoblot analysis of ATAD3A expression in HCC tissues and their adjacent normal tissues. GAPDH was used as a loading control. h. Xenograft tumors derived from shATAD3A LM3 cells with/without miR-210-5P antagomir under sorafenib treatment. i-l. Representative images of tumor growth (i), and the tumor volume (j), tumor weight (k) and tumor growth curve (l) in the indicated groups. m. Schematic representation of ATAD3A-mediated mitophagy during hypoxia-induced sorafenib resistance in HCC cells. Each bar represents the mean ± SEM of three independent experiments. *P < 0.05 and ** P < 0.01

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