Fig. 3

CircSOD2 promotes in vitro liver cancer cell proliferation and tumorigenesis in vivo. a CircSOD2 expression after silencing with siRNA. HEPG2 (b) HUH7 (c) Cell growth and cell migration (d) following knockdown of circSOD2. e Statistic results of cell migration. f Cell cycle following knockdown of circSOD2. g statistic results of F. h Cell apoptosis following knockdown of circSOD2. i CircSOD2 depleted from HEPG2 or HEPG2 control cells was injected into nude mice, tumor volume was monitored. j Mice was sacrificed 5 weeks later; tumor picture was taken. *P < 0.05, **P < 0.01, ***P < 0.001