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Fig. 8 | Journal of Experimental & Clinical Cancer Research

Fig. 8

From: CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway

Fig. 8

STAT3 upregulates circSOD2 expression in a feedback way. a Diagram of STAT3 binding sites on circSOD2 promoter. b ChIP-qPCR results of STAT3 binding to circSOD2 promoter. DNA region that is close to circSOD2 promoter without STAT3 binding site and IgG were used as control. c CircSOD2 expression after deleting STAT3. d Western blots detect STAT3 expression after deleting STAT3, GAPDH was used as control. e A schematic model of the mechanism underlying the role of circSOD2 in HCC. *P < 0.05, **P < 0.01, ***P < 0.001

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