Fig. 1

Bioinformatics analysis revealed genes that are potentially associated to radioresistance in LUAD. a Previous studied showed change of transcriptome profiles of radiation-resistant A549 cells under irradiation. This study performed an enrichment analysis of the significantly changed mRNA (|log2 fold change| > 1.0 and P < 0.05) using a functional enrichment analysis tool, FunRich 3.1.3 (http://funrich.org/index.html). b Previous studies also manifested that the m6A level of thousands of mRNA was affected by METTL3. This study performed an intersection analysis between the changed mRNA and METTL3-regulated mRNA. c TCGA dataset (http://starbase.sysu.edu.cn/index.php) showing expression levels of TRIAP1, DRG1, SEMA3A and VANGL1 in LUAD and normal lung tissues. d Starbase (http://starbase.sysu.edu.cn/index.php) and (E) Gepia (http://gepia.cancer-pku.cn/) showing the survival time and percentage of survival in LUAD patients with high or low TRIAP1, DRG1, SEMA3A and VANGL1 levels