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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

Fig. 3

Predominant histone modification states in DIPG tumor tissue. a K27 mono-methylation and K36 di-methylation are predominant modification states on H3.1 and H3.3 tails in DIPG tumor tissue (n = 9). * p < 0.05 compared to all the other modification states (Tukey HSD, Post Hoc Tests, one way ANOVA). b H4K16ac is the predominant acetylated residue in DIPG tumor tissue (n = 9). * p < 0.05 compared to all the other modification states (Tukey HSD, Post Hoc Tests, one way ANOVA). c,d H3.3K36me2 abundance positively correlates with H3.1K36me2, and negatively correlates with H3.3K27me1 (Pearson Correlation = 0.87 and − 0.84, respectively, all p < 0.01. Pearson Correlation, two-tailed). e, f H4K16ac abundance positively correlates with H3.3K36me2, and negatively correlates with H3.3K27me1 (Pearson Correlation = 0.82 and − 0.94, respectively, all p < 0.01. Pearson Correlation, two-tailed)

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