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Table 3 Effects of bromodomain inhibition with JQ1 on relative histone peptide abundance in SF8628 cells

From: Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

Histone code

Mean

Fold (JQ1/DMSO)

p_SF8628

Baseline

DMSO 24 h

DMSO 48 h

JQ1 24 h

JQ1 48 h

24 h

48 h

24 h

48 h

H3.1K27me1

31.4

31.1

28.7

32.8

33.5

1.1

1.2

< 0.05

< 0.05

H3.1K27me2

19.6

19.0

19.3

22.4

21.7

1.2

1.1

< 0.01

0.21

H3.3K27me2

6.9

6.7

7.7

7.8

9.8

1.2

1.3

< 0.01

0.33

H3.3K27M

21.0

21.5

19.0

24.4

26.0

1.1

1.4

< 0.05

< 0.05

H3.3K36me1

5.4

6.4

6.5

7.5

8.3

1.2

1.3

< 0.05

0.07

H3.3K36ac

12.0

13.5

16.0

9.7

7.9

0.7

0.5

< 0.05

< 0.01

H3K18ac

9.7

6.4

7.7

4.8

5.7

0.8

0.7

< 0.05

0.05

H3K79me2

11.0

12.7

11.2

12.3

14.4

1.0

1.3

0.86

< 0.05

H4K20me1

1.7

2.9

1.7

1.9

2.0

0.7

1.2

< 0.05

0.29

H4K20me2

91.7

89.2

87.1

94.8

89.2

1.1

1.0

< 0.01

0.38