Histone code | Mean | Fold (JQ1/DMSO) | p_SF8628 | ||||||
---|---|---|---|---|---|---|---|---|---|
Baseline | DMSO 24 h | DMSO 48 h | JQ1 24 h | JQ1 48 h | 24 h | 48 h | 24 h | 48 h | |
H3.1K27me1 | 31.4 | 31.1 | 28.7 | 32.8 | 33.5 | 1.1 | 1.2 | < 0.05 | < 0.05 |
H3.1K27me2 | 19.6 | 19.0 | 19.3 | 22.4 | 21.7 | 1.2 | 1.1 | < 0.01 | 0.21 |
H3.3K27me2 | 6.9 | 6.7 | 7.7 | 7.8 | 9.8 | 1.2 | 1.3 | < 0.01 | 0.33 |
H3.3K27M | 21.0 | 21.5 | 19.0 | 24.4 | 26.0 | 1.1 | 1.4 | < 0.05 | < 0.05 |
H3.3K36me1 | 5.4 | 6.4 | 6.5 | 7.5 | 8.3 | 1.2 | 1.3 | < 0.05 | 0.07 |
H3.3K36ac | 12.0 | 13.5 | 16.0 | 9.7 | 7.9 | 0.7 | 0.5 | < 0.05 | < 0.01 |
H3K18ac | 9.7 | 6.4 | 7.7 | 4.8 | 5.7 | 0.8 | 0.7 | < 0.05 | 0.05 |
H3K79me2 | 11.0 | 12.7 | 11.2 | 12.3 | 14.4 | 1.0 | 1.3 | 0.86 | < 0.05 |
H4K20me1 | 1.7 | 2.9 | 1.7 | 1.9 | 2.0 | 0.7 | 1.2 | < 0.05 | 0.29 |
H4K20me2 | 91.7 | 89.2 | 87.1 | 94.8 | 89.2 | 1.1 | 1.0 | < 0.01 | 0.38 |