Histone tail analysis reveals H3K36me2 and H4K16ac as epigenetic signatures of diffuse intrinsic pontine glioma

Table 4 Effects of bromodomain inhibition with JQ1 on relative histone peptide abundance in U87 cells

Histone code	Mean					Fold (JQ1/DMSO)		p_U87
Histone code	Baseline	DMSO 24 h	DMSO 48 h	JQ1 24 h	JQ1 48 h	24 h	48 h	24 h	48 h
H3.1K27me2	34.7	34.2	35.2	37.0	38.6	1.1	1.1	< 0.05	< 0.05
H3.1K27me3	10.0	11.0	12.2	13.1	14.4	1.2	1.2	< 0.05	< 0.05
H3.1K36me1	19.9	19.6	18.3	17.9	19.0	0.9	1.0	< 0.05	0.39
H3.1K36me3	15.4	16.4	15.3	14.9	14.1	0.9	0.9	< 0.05	< 0.05
H3.3K36me1	10.7	11.1	10.4	11.4	12.5	1.0	1.2	0.51	< 0.05
H3.3K36ac	13.3	11.9	14.1	10.9	9.6	0.9	0.7	0.30	< 0.01
H3K14ac	45.0	37.3	28.5	30.2	26.8	0.8	0.9	< 0.05	0.38
H3K79me1	24.8	27.7	26.6	23.9	23.7	0.9	0.9	< 0.01	0.14
H3K4me1	21.1	17.6	16.7	12.8	15.5	0.7	0.9	< 0.01	0.69
H4K5ac	4.9	5.6	5.4	4.6	4.6	0.8	0.8	< 0.01	< 0.05

ISSN: 1756-9966