Fig. 2
The transcriptional program of CD34+ cells differs between TN and JAK2V617F MF patients. Signatures IL6/JAK/STAT3 signaling (a) and KRAS (b) enriched in JAK2V617F-mutated and TN patients, respectively (GSEA). c Gene expression differences in cell adhesion-, apoptosis-, immune response-, proliferation- and vesicle-related genes between JAK2V617F-mutated (n = 3) and TN (n = 3) patients. Each column represents a different patient. Data were standardized through a z-score transform; color changes within a row indicate expression levels relative to the mean and rescaled on the transcript standard deviation. Genes are ranked according to average linkage hierarchical clustering. d-e Cell adhesion-related signatures in TN, identified by GSEA and enriched in TN. f Apoptosis-related signatures enriched in the JAK2V617F cohorts. (NES: normalized enrichment score; TN: triple-negative)