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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Distinct profile of CD34+ cells and plasma-derived extracellular vesicles from triple-negative patients with Myelofibrosis reveals potential markers of aggressive disease

Fig. 4

Survival and migration of CD34+ cells from TN patients are not increased by pro-inflammatory cytokines. a CD34+ cells from JAK2V617F (n = 4) or TN (n = 4) patients were in vitro treated with combined pro-inflammatory factors such as IL-1β, TNF-α, and IL6 and the fold-change of cell viability was assessed after Annexin V/PI staining, as described in Methods. Dot lines were used to mark control samples without any treatment, as fold-change = 1. b Spontaneous migration and toward CXCL12, alone or in combination with pro-inflammatory cytokines, were observed in JAK2V617F-derived (n = 4) CD34+ cells as compared with the TN (n = 4) counterparts. Results are expressed as mean percentages ± SEM of input (*p ≤ 0.05; **p ≤ 0.01)

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