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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Fig. 3

MIR22HG is involved in signaling pathways that affect cancer progression. a MIR22HG negatively regulates the Wnt/β-catenin signaling pathway by downregulating the expression of β-catenin, cyclin D1 and c-myc to inhibit cell proliferation and migration in CCA. b MIR22HG blocks the SMAD complex, preventing its binding to the promoter of SNAI1 and further suppressing the EMT signaling pathway. c MIR22HG inhibits the Notch signaling pathway by downregulating nuclear Notch2 and HEY1 expression in GC. d MIR22HG activates the STAT3 signaling pathway to promote the proliferation, migration and invasion of ESCA

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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