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Fig. 4 | Journal of Experimental & Clinical Cancer Research

Fig. 4

From: Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Fig. 4

MIR22HG inhibits tumor progression through interactions with proteins. a MIR22HG interacts with the YBX1 protein, increasing its stability, leading to the upregulation of MET expression and the inhibition of p21 expression, thus suppressing the proliferation and antiapoptosis of NSCLC cells. b MIR22HG specifically interacts with HuR to increase MIR22HG stability and regulate its subcellular localization, resulting in the degradation of HuR-stabilized oncogenes such as β-catenin, CCNB1, HIF1A, BCL2, COX2, and C-FOS

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