Fig. 5

MIR22HG interacts with miR-22 as a host gene. a MIR22HG, as a host gene of miR-22, upregulates the expression of miR-22-3p/5p, leading to the attenuated expression of its two direct targets, SFRP2 and PCDH15, thus promoting GBM cell proliferation and invasion. AC1L6JTK, a specific small-molecule inhibitor, efficiently suppresses tumor growth in vivo by blocking the processing of pre-miR-22 into mature miR-22. b MIR22HG markedly upregulates miR-22-3p expression levels and drives miR-22-3p to target HMGB1, leading to the deactivation of HMGB1 signaling