Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Table 1 Functional characterization of MIR22HG in various tumors

Tumor type	Expression	Role	Functional role	Related genes and pathways	References
thyroid carcinoma	down regulated	tumor suppressor	cell proliferation, migration, invasion and apoptosis	Hippo signaling pathway, miR-24-3p and p27kip1	[21, 22]
hepatocellular carcinoma	down regulated	tumor suppressor	cell proliferation, migration, and invasion	miR-22-3p, HMGB1, HuR, miR-10a-5p, NCOR2, β-catenin and EMT	[23, 24]
endometrial carcinoma	down regulated	tumor suppressor	cell proliferation, apoptosis and the cell cycle	miR-141-3p and DAPK1	[25]
cholangiocarcinoma	down regulated	tumor suppressor	cell proliferation, migration, and invasion	Wnt/β-catenin signaling pathway, β‐catenin, cyclin D1 and c‐myc	[26]
colorectal cancer	down regulated	tumor suppressor	cell proliferation and migration	SMAD2, SMAD4, TGFβ signaling pathway, EMT, and CD8A	[27]
gastric cancer	down regulated	tumor suppressor	cell proliferation, migration, and invasion	Notch2 signaling pathway and HEY1	[28]
esophageal adenocarcinoma	up regulated	tumor promoter	cell proliferation, migration, invasion and apoptosis	STAT3, c-Myc and p-FAK	[29]
non-small cell lung cancer	down regulated	tumor suppressor	cell proliferation, migration, and invasion	Ybx1, MET, and p21	[30]
glioblastoma	up regulated	tumor promoter	cell proliferation and invasion	MiR-22-3p/miR-22-5p, SFRP2/PCDH15, ACIL6JTK and Wnt/β-catenin signaling pathway	[31]

ISSN: 1756-9966