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Table 1 Functional characterization of MIR22HG in various tumors

From: Emerging impact of the long noncoding RNA MIR22HG on proliferation and apoptosis in multiple human cancers

Tumor type Expression Role Functional role Related genes and pathways References
thyroid carcinoma down
regulated
tumor suppressor cell proliferation, migration, invasion and apoptosis Hippo signaling pathway,
miR-24-3p and
p27kip1
[21, 22]
hepatocellular carcinoma down
regulated
tumor suppressor cell proliferation, migration, and invasion miR-22-3p, HMGB1, HuR,
miR-10a-5p, NCOR2, β-catenin and EMT
[23, 24]
endometrial carcinoma down
regulated
tumor suppressor cell proliferation, apoptosis and the cell cycle miR-141-3p and DAPK1 [25]
cholangiocarcinoma down
regulated
tumor suppressor cell proliferation, migration, and invasion Wnt/β-catenin signaling pathway, β‐catenin, cyclin D1 and c‐myc [26]
colorectal
cancer
down
regulated
tumor suppressor cell proliferation
and migration
SMAD2, SMAD4, TGFβ signaling pathway,
EMT, and CD8A
[27]
gastric cancer down
regulated
tumor suppressor cell proliferation, migration, and invasion Notch2 signaling pathway and HEY1 [28]
esophageal adenocarcinoma up
regulated
tumor promoter cell
proliferation, migration, invasion and
apoptosis
STAT3, c-Myc and p-FAK [29]
non-small cell lung cancer down
regulated
tumor suppressor cell proliferation, migration, and invasion Ybx1, MET, and p21 [30]
glioblastoma up
regulated
tumor promoter cell proliferation and
invasion
MiR-22-3p/miR-22-5p,
SFRP2/PCDH15,
ACIL6JTK and
Wnt/β-catenin signaling pathway
[31]