Fig. 1

In HCCs, high expression of glycolysis-related metabolites and genes was associated with low miR-192-5p level. a Available omics dataset in Cohort 1 (n = 176). b Spearman correlation was performed between miR-192-5p and metabolome in 22 HCC cases of HCC Cohort 1. 17 metabolites were significantly correlated with miR-192-5p with |r-value| > 0.4 (p < 0.05). c 652 genes significantly correlated with miR-192-5p (Pearson correlation, |r-value| > 0.4) in Cohort 1 were used for KEGG pathway enrichment analysis. d Major metabolites and genes in glycolysis and glycolysis side pathways. e Log₂ ratios of glycolysis-related metabolites and genes in HCC^192Low vs. HCC^192High HCCs of Cohort 1. f Hierarchical clustering analysis with glycolysis-related genes in Cohort 1. Red bar and green bar represent CSC biomarker positive and negative HCC cases, respectively. miR-192-5p expression levels were also shown. g ECAR and OCR measurement in Huh7 cells infected with lentivirus miRZip-ctrl or miRZip-192. h ECAR and OCR measurement in HLF and HLE cells infected with lentivirus pmiR-ctrl or pmiR-192