Fig. 7

Suppression of hsa_circ_0001829 expression inhibits tumor growth and aggressiveness in vivo. a-c) Schematic representation (a), in vivo growth curve (b), and weight at the end points (c) of xenograft tumors formed by subcutaneous injection of GES-1-T cells stably transfected with sh-NC or sh-circRNA-1# into the flanks of NOG mice (n = 5 for each group). d Representative images (left panel) and quantification (right panel) of immunohistochemical staining showing the expression of PCNA, MMP2 and SMAD2 within xenograft tumors from the sh-NC and sh-circRNA-1# groups. e-g Representative images (e), quantification (f) of lung metastatic colonization and H&E staining (g) of NOG mice treated with tail vein injection of GES-1-T cells stably transfected with sh-NC or sh-circRNA-1# (n = 5 for each group). *p < 0.05, ** p < 0.01