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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression

Fig. 7

Schematic diagram for this article. The schematic diagram shows that adequate amounts of endogenous circCDKN2B-AS1 are produced with the development of cervical cancer. The IMP3 protein is recruited by circCDKN2B-AS1 to bind to the 3’UTR of HK2 mRNA, thereby stabilizing HK2 mRNA and promoting aerobic glycolysis and the malignant phenotype of cervical cancer. Knockdown of circCDKN2B-AS1 and mutation or blockade of the binding site between circCDKN2B-AS1 and IMP3 can impede the binding of IMP3 to the 3’UTR of HK2 mRNA, reduce HK2 expression levels and suppress aerobic glycolysis and progression in cervical cancer in vivo and in vitro

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