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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Choline kinase alpha impairment overcomes TRAIL resistance in ovarian cancer cells

Fig. 5

CHKA silencing increased TRAIL-R2 membrane expression and triggering/function. a. Expression of total TRAIL-R2 protein assessed by both flow cytometry after cells permeabilization (left panel) and Western blotting (right panel) in siCHKA and siNT cell lines. b. Membrane surface expression of TRAIL-R2 detected by flow cytometry after CHKA silencing and recovery of ChoKα expression. In both A and B, representative experiments are shown. Fluorescence index are reported. C. Percentage of growth inhibition obtained following 16 h treatment with specific anti-TRAIL-R2 agonist antibody; asterisks are referred to statistically significant differences

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