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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Long noncoding RNA MIR31HG and its splice variants regulate proliferation and migration: prognostic implications for muscle invasive bladder cancer

Fig. 6

MIR31HG is required for BLCA tumorigenesis. a-c Cell viability was quantified using the MTS assay. T24 (A), UMUC3 (b) and SCaBER (c) cells with MIR31HG knockdown by siRNA showed lower cellular viability compared with control group with scramble siRNA (si-NC). d Colony formation was detected by measuring the stained cells after 7 days. T24, UMUC3, and SCaBER cells with MIR31HG knockdown showed fewer cell colonies compared to control group. e Staining intensity percentage of colony formation assay was analyzed by ImageJ software. BLCA cells with MIR31HG knockdown showed decreased staining intensity compared with control group. f Wound healing assay was measured using cell culture inserts. T24, UMUC3, and SCaBER cells with MIR31HG knockdown showed more open wound area compared with control group after 12 h. g Open wound area was quantified by calculating the percentage of change in open wound area after 12 h. BLCA cells with MIR31HG knockdown showed fewer changes in open wound area compared to the control group

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