Fig. 5
From: Noncoding RNAs regulate alternative splicing in Cancer
NcRNAs regulate AS through the posttranslational regulation of SFs. a Posttranslational chemical modifications. The lncRNA MALAT1 contributes to SRSF1 phosphorylation by stimulating both the expression and activity of SRPK1, thereby promoting SRSF1-mediated AS of the AKAP-9 pre-mRNA and enhancing the expression of the AKAP-9 isoform, which exacerbates CRC. b Decoy SFs. For example, the lncRNA TPM1-AS can directly block the binding between the SF RBM4 and TPM1 pre-mRNA and regulate AS, inhibiting the progression of cancer. c Chromatin remodeling. The lncRNA asFGFR2 recruits PRC2 and KDM2a to chromatin to form a chromatin environment that disrupts the binding of MRG15-PTB. This disruption alters the location of the SF PTB, promoting FGFR2 mRNA with exon IIIb inclusion and consequently repressing HCC progression. d Encoding functional peptides. The lncRNA HOXB-AS3 encodes the peptide HOXB-AS3, which targets hnRNPA1 and blocks it from binding to PKM pre-mRNA flanking exon 9, decreasing the expression of the PKM2 isoform and consequently repressing the growth of colon cancer