Fig. 2

MINPP1 gene was identified to be an anti-oncogene in HBV-positive HCC. a RT-qPCR results showing MINPP1 expression level in hepatoma cell lines. b Cell proliferation was assessed with the CCK-8 assay in Hep3B cells with MINPP1 knockdown (left) and overexpression (right). c The real-time cell proliferation of Hep3B cells with MINPP1 knockdown and overexpression was determined by CCK-8 assay. d Scrape motility were measured by cell migration assays at 0, 24, and 48 h in the Hep3B cells with MINPP1 knockdown or overexpression. The wound healing rate was tested by Image J software. e Left: The tumor formation in nude mice injected subcutaneously with Hep3B cells overexpressing MINPP1 (right) and control cells (left). Right: The harvested xenograft tumors. f The tumor volume was measured after nude mice were injected with Hep3B cells overexpressing MINPP1 and control cells. g The tumor weight was measured after the nude mice were injected with the Hep3B cells overexpressing MINPP1 and control cells. ^**P < 0.01, ^***P < 0.001, ^****P < 0.0001