Skip to main content
Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Promotion of epithelial-mesenchymal transformation by hepatocellular carcinoma-educated macrophages through Wnt2b/β-catenin/c-Myc signaling and reprogramming glycolysis

Fig. 7

The inhibition of Wnt2b/β-catenin signaling reduces the tumour-promoting effect of HCC-TAMs in vivo. SMMC-7721 cells (6 × 106) with or without the indicated TAMs (1.5 × 106) were mixed with Matrigel (at ratio 4:1) and subcutaneously injected into the right subaxillary of 6-week old immunodeficient mice (n = 6 mice/group). a, d Representative images of the subcutaneous tumors from each group. b, e Growth of subcutaneous tumours (left); the average tumour weight of each group at the time of euthanisation(right). c, f Representative images of immunohistochemistry staining of vimentin, E-cadherin, β-catenin, c-Myc in tumour tissues. g Overall survival HCC patients related to indicated gene expression levels, were generated by the GEPIA2 database via Kaplan–Meier analysis. HCC, hepatocellular carcinoma; TAMs, tumour-associated macrophages; IHC, Immunohistochemistry. Data are presented as mean ± SEM (*p < 0.05, **p < 0.01 and ***p < 0.001)

Back to article page