Fig. 9

Inhibition of exosome secretion enhances miR-375 inhibition proliferation and invasion of glioma in vivo. a. Bioluminescence imaging indicating tumour size over time. b. Luminescent signal intensity of glioma-bearing mice in two groups. c. Evaluation of animal survival carried out according to Kaplan–Meier analysis. d. IHC staining of CTGF, Ki-67, and MMP9 in GW4869 group and DMSO group samples. Quantification of CTGF, Ki-67, and MMP9 intensity in IHC staining. Scale bar for 20X (left) = 100 μm, and 40X (right) =50 μm. Data are presented as mean ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001. ns, not significant