Fig. 8

Lnc-GAN1 repressed cell proliferation through cell cycle signaling pathway. a KEGG pathway analysis of differentially expressed genes that were generated by the SurePrint G3 Human Microarray analysis of A549-NC and A549-lnc-GAN1 stable cells indicates that cell cycle signaling pathway is involved in lnc-GAN1 inhibiting NSCLC progression. b Overexpressed lnc-GAN1 elevates PTEN protein and decreases Cyclin D1 and CDK4 proteins in A549 and H460 cells, while lnc-GAN1 downregulation has the opposite effects in H1299 and H1650 cells. c Molecular mechanism of lnc-GAN1