Fig. 3
From: ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma
Knockdown of ACTN1 suppresses in vivo tumor growth of HCC. a Images of tumors from mice subcutaneously inoculated with sh-ACTN1–1, sh-ACTN1–2 or sh-Ctrl MHCC-97H cells (n = 5). b Statistical analysis of tumor weight from sh-ACTN1–1, sh-ACTN1–2 and sh-Ctrl groups. c IHC analysis of PCNA staining in the tumors of sh-ACTN1–1, sh-ACTN1–2 and sh-Ctrl groups. Scale bar: 50 μm. d Representative images of liver tissues from mice orthotopically inoculated with sh-ACTN1–1 or sh-Ctrl MHCC-97H cells. e H&E staining in liver tissues from sh-ACTN1–1 or sh-Ctrl group. Statistical analysis of intrahepatic metastatic foci is shown at right. Scale bar: 500 μm. f Kaplan-Meier survival curve analysis of the mice survival in the sh-ACTN1–1 and sh-Ctrl group. **P < 0.01