Fig. 6
From: ACTN1 supports tumor growth by inhibiting Hippo signaling in hepatocellular carcinoma
The molecular mechanism of ACTN1 in regulating Hippo signaling and cell proliferation of HCC. a ACTN1 competitively interacts with MOB1 and decreases the phosphorylation of LATS1/YAP, and ultimately suppresses Hippo signaling and promotes the proliferation/migration of HCC. b If ACTN1 is knocked down, MOB1 can interact with LATS1, then increase the phosphorylation of LATS1/YAP and activate Hippo signaling, which lead to the inhibitory effects on the tumor growth of HCC