Table 1 Linkers connecting the two moieties in the hybrid proteins
From: A receptor-antibody hybrid hampering MET-driven metastatic spread
Name | Length | Amino acid composition | Features |
|---|---|---|---|
L1 | 60 | GGSSGSGSGSTGTSSSGTGTSAGTTGTSASTSGSGSGGGGGSGGGGSAGGTATAGASSGS | flexible |
L2 | 17 | GGGGSGGGGSGGGGSGG | flexible |
L3 | 32 | GGGGSGGGGSGGGGSGGGGSGGGGSGGGGSGG | flexible |
L4 | 22 | AEAAAKEAAAKEAAAKEAAAKA | rigid |
L5 | 45 | AEAAAKEAAAKEAAAKEAAAKAAAEAAAKEAAAKEAAAKEAAAKA | rigid |
L6 | 134 | GGGGSGGGGSGGGGSAEAWYNLGNAYYKQGDYQKAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYQKAIEYYQKALELDPNNAEAWYNLGNAYYKQGDYQKAIEDYQKALELDPNNGGGGSGGGGSGGGGSGG | mixed (flexible/rigid) |