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Fig. 1 | Journal of Experimental & Clinical Cancer Research

Fig. 1

From: The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Fig. 1

Abnormal HSF1 activation is an early molecular event in pancreatic cancer tumorigenesis. a-b Representative IHC staining of HSF1 positive cells and Masson staining of collagen I positive fibrosis in all stages of in all stages of the tumorigenesis of human pancreatic cancer (normal acinar and ADM (a), early PanINs, late PanINs, invasive and infiltrative PDAC tissues (b). c Representative histopathology (H&E staining) and the IHC staining of HSF1-positive cells in all stages of the tumorigenesis of murine (KC mice) pancreatic cancer. d The relative HSF1 expression in pancreatic cancer tissues of mutant KRAS samples (KRASMUT) and non-mutant KRAS samples (KRASWT) samples according to TCGA datasets. e The relative HSF1 expression in normal pancreas tissues and pancreatic cancer tissues according to TCGA & GTEx datasets. f The relative HSF1 protein expression in pancreatic ductal progenitor cell line hTERT-HPNE and pancreatic cancer cell lines BxPC-3, CFPAC-1, PANC-1, MIAPaCa-2, and AsPC-1. g Representative IHC staining of HSF1-positive cells in pancreatic acinar cells from C mice and KC mice pancreatic cancer. h-i Representative histopathology (H&E staining) and IHC staining of HSF1-positive cells in the acute pancreatitis tissues (h) and chronic pancreatitis tissues (i) of KC mice. Scale bars = 10/25 μm. * P < 0.05, ns P > 0.05

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