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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer

Fig. 3

Pharmacological inhibition of HSF1 suppressed the formation of ADM in vivo. a Double-label IF staining showed the expression of amylase and CK19 in the pancreas of vehicle C mice, vehicle KC mice and KC mice treated with KRIBB11. b Representative histopathology (H&E staining) and the IHC staining of amylase (acinar marker), CK19 (ductal marker) in the pancreas of C mice treated with short-term cerulein, KC mice treated with short-term cerulein and KC mice treated with short-term cerulein plus KRIBB11. c-e Quantification of the PanINs area (c), the amylase-positive acinar area (d) and the CK19-positive ductal area (e) per 400× field in the pancreas of C mice treated with short-term cerulein, KC mice treated with short-term cerulein and KC mice treated with short-term cerulein plus KRIBB11. f Western blotting assay were performed to evaluate the effect of KRIBB11 on the expression of amylase, CK19 and HSP70 in KC mice (short-term cerulein) acute pancreatitis tissues. Scale bars = 50 μm. * P < 0.05

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